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nov 17, 2020 Aljona Svetozaj Kolekcija Aljona Svetozaja, udana Rijeka Expression of GLUT1 (SLC2A1) is associated with aggressive tumor progression and poor patient prognosis in human breast cancer. Our study investigated the role of GLUT1 (SLC2A1), a glucose transporter in breast cancer. We evaluated GLUT1 expression in a series of breast tumors and assessed its correlation with several clinicopathological features. GLUT1 expression was assessed in 96 invasive breast tumors. GLUT1 expression in tumors was correlated with several clinicopathological features. Additionally, the biological effects of GLUT1 were analyzed by cell growth assays and xenograft tumor growth assays. GLUT1 was overexpressed in both human breast cancer cell lines and breast cancer tumors. GLUT1 overexpression resulted in increased cell proliferation and tumor growth, and reduced apoptosis. The aggressive nature of breast cancer cells with high GLUT1 expression was associated with HER-2 overexpression and high expression of c-Myc. GLUT1 expression was significantly correlated with histological grade and tumor size. Multivariate Cox regression analyses identified GLUT1 as an independent risk factor for breast cancer-related death. Patients with tumors exhibiting high GLUT1 expression had shorter survival time and higher risk of recurrence than patients with tumors exhibiting low GLUT1 expression. Importantly, GLUT1 overexpression promoted tumorigenesis of estrogen receptor-negative breast cancers, whereas it suppressed tumorigenesis of estrogen receptor-positive breast cancers. Furthermore, GLUT1 overexpression promoted cell growth, invasion, and colony formation of estrogen receptor-negative breast cancer cells but inhibited the same processes in estrogen receptor-positive breast cancer cells. Our data suggest that GLUT1 is a useful prognostic indicator for breast cancer patients and may promote the development of estrogen receptor-negative breast cancer.Surgical treatment of familial amyloid polyneuropathy: clinical outcome and prognostic factors. Surgical treatment of autonomic dysfunction in familial amyloid polyneuropathy (FAP) is considered a life-prolonging therapy, because of a presumed improvement of cardiac and gastrointestinal function. In a single-center prospective study, 40 FAP patients underwent gastric resection in 17, gastrojejunostomy in 19, and multiple-point suture of the stomach in 4. After surgery the estimated




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